Dendritic Computations in Learning & Disease
I am a neuroscientist at the Institute of Experimental Epilepsy and Cognition research (IEECR). My research goals focus on dendrites in neuronal network, and ultimately how dendritic computations contribute to behaviour and go awry in disease.
Dendrites are the intricate and fascinating input structure of neurons with 10’s of thousands of synaptic inputs. The structure is not only beautiful but tightly tuned to perform computations that determine neuronal network activity in behavior.
Research Projects
Dendritic computation from network computation to disease
Dendrites in Epilepsy
Investigating the contribution of dendritic changes to pathology of acquired and genetic epilepsies.
Dendritic Morphology and Learning
Investigating how novel dendritic structures contribute to dendritic computations and learning.
GECI: Cautionary tale of Tools
Common tools to investigate activity in the brain resulted in artefacts. What do they look like and how to avoid them.
News & Updates
Interested in synaptic neuroscience? We have an open PhD student position for exploring how rapid remodelling of astrocytes controls excitory synapse function and their plasticity. Further details on the project and the position can be found here:
Postdoc position open in the Tavosanis Lab! We extended the deadline- check it out here:
https://jobs.rwth-aachen.de/index.php?ac=jobad&id=7855
Very happy our cautionary tale of GECI expression in the hippocampus is out in @eLife.
https://elifesciences.org/articles/93804
We describe Ca2+ waves though the hippocampus. Mesmerising but artefact of GECI expression.
Also a tweet print . 1/3
preprint Alert📢 Time to talk about the🐘 in the room of genetically encoded Calcium indicators (GECIs). These indicators are widely used to report activity in the brain and an invaluable tool, but the expression of these GECIs can change activity. 🧵1/7
https://biorxiv.org/cgi/content/short/2023.11.08.566169v1